Saturday, October 24, 2020

The ABCs of Vitamins Foundation

The ABCs of Vitamins

Vitamins are natural components of foods and necessary for normal physiologic functioning. One of the most critical responsibilities of vitamins is their role as co-factors for enzymes.
While vitamins are essential, unlike macronutrients, they don’t function as direct energy sources.
The general categories of vitamins include fat-soluble and water-soluble, depending on whether they dissolve well in either fat or water, respectively.
Vitamins A, D, E, and K are classified as fat-soluble. These are mostly absorbed passively in the GI tract, and usually must be transported bound to dietary fat.
In the body, fat-soluble vitamins are usually found in the portion of the cell, which contains fat, including cell membranes, lipid droplets, etc.
These vitamins are typically excreted through our feces.
Due to the unique storage capacity of fat-soluble vitamins, it’s not necessary to consume them every day.
B vitamins and vitamin C are water-soluble. These vitamins are absorbed both by passive and active mechanisms in the gastrointestinal tract. They rely on carrier proteins for transport.
Since body water is always being turned over, water-soluble vitamins are not stored in large amounts in the body; they’re typically excreted in the urine along with their breakdown products. And for this reason, it’s important to get them on a daily or weekly basis.
Also interesting to note is that water-soluble vitamins can also be lost in water during cooking and storage. Which means the best methods to preserve vitamins include steaming, sauteing, roasting, and microwaving. That’s why boiling in water, and then discarding the water, will likely result in loss of some vitamins.
Remember that frozen and canned vegetables and fruits were harvested and then immediately preserved, so unless they are boiled after opening, they are likely to have a high nutrient content. 
Vitamins are not a one-size-fits-all situation. Many factors determine our needs, including gender, GI health, medication use, stress, exercise, and age-related changes.
All About Minerals
Like vitamins, minerals are not direct sources of energy, yet are still considered essential in the human diet. They serve as building blocks for body structures: they form the foundation of teeth and bones, and help to construct other cells and enzymes.
Minerals are already in the simplest form possible, they are elements, so the body doesn’t need to break them down before absorption. Further, minerals won’t be degraded on exposure to heat, so minerals in food stay unharmed during storage and cooking.
The minerals in foods come from the environment, such as soil and water taken up into plants during the growing process, and then incorporated into the animals that eat the plants. Whether humans eat the plant directly or the animal product, all of the minerals in the food supply originate from Mother Nature. 
Minerals can act as co-factors in enzymatic reactions or as enzymes themselves. Minerals can also act as electrolytes that maintain the electrochemical gradient across the cells of our bodies.
Other molecules found in food, such as phytates and oxalates, can alter one’s ability to absorb minerals. This only becomes an issue for those whose intake is limited to just a handful of foods that are high in these compounds (e.g. cultures eating only rice or corn, etc.). In the context of a mixed diet, with a variety of whole foods, they are unlikely to pose an issue.
It’s also important to note that if someone buys a certain vitamin or mineral at the store to replace a vitamin or mineral they are missing out on from food, it’s not quite the same thing.
The micronutrients in whole foods are a package deal. They come with other compounds that work together, creating a cascade response in the body. It’s hard to duplicate that with an isolated supplement.

Phytonutrients
Like vitamins and minerals, phytonutrients - nutrients found in plants - don’t directly provide energy to the body. Yet they do offer a variety of health benefits.
Of course, while scientists are continually discovering “new” phytonutrients (there are over 10,000 already identified), it’s important to remember that these discoveries simply mean that someone isolated the nutrient in a lab and named it. In other words, that nutrient has always been part of the plant.
Bottom line: Eating plants is good. Not only because of the nutrients we know about. But because of the ones we don’t yet know about.
Phytonutrients not only give plants color, they indicate which disease-fighting nutrients are inside. And deficiencies in phytonutrient intake might increase the risk of various chronic diseases.
One report indicated that 31% of folks don’t get enough greens, 22% don’t get enough reds, 21% don’t get enough yellows and oranges, 14% don’t get enough whites, and 12% don’t get enough purples and blues.
Some phytonutrients are so powerful that they can influence our response to the world around us.
For example, naringenin in grapefruit, influences how we metabolize drugs. Raspberry seed oil has a sun protection factor. And garlic may have a blood thinning effect.
Phytonutrients work through various mechanisms, including:
  • functioning as antioxidants
  • influencing hormonal function
  • protecting DNA from carcinogens
  • anti-bacterial and anti-viral properties
  • reducing inflammation
  • influence blood coagulation
  • inhibiting fat synthesis
And while phytonutrients sound appealing, they can work in complex ways.
For example, some work by mildly stressing cells in the body, ultimately making them stronger by building internal defense mechanisms (this is called hormesis).

Preventing Catabolic Muscle Wasting - Cachexia and Sarcopenia

Loss of muscle and fat tissue due to illness is called cachexia. The general loss of muscle mass that occurs with advancing age is called sarcopenia. In both cachexia and sarcopenia, muscle loss can lead to frailty and declining quality of life, as well as increased risk of death, infection, and falls; slower wound healing; and reduced exercise capacity. The term “catabolic wasting” encompasses both cachexia and sarcopenia.
A number of nutritional interventions may be useful to prevent and treat catabolic wasting, including whey proteincreatine, and the amino acids glutamine, arginine, and HMB (hydroxy-methylbutyrate) amino acid ( leucine derivative).

Symptoms and Diagnosis

  • Weakness, fatigue, and difficulties in daily living
  • May be difficult to distinguish between cachexia and sarcopenia; aging individuals may experience both simultaneously.
  • Moderate-to-severe cachexia or sarcopenia can be diagnosed by observing loss of muscle mass, strength, and tone.
Some researchers have proposed that cachexia and sarcopenia should be diagnosed by calculating lean and fat body mass by imaging techniques such as MRI (magnetic resonance imaging).

Risk Factors

Cachexia
  • Chronic diseases, such as cancer, AIDS, heart failure, chronic lung disease, and inflammatory bowel disease
Sarcopenia
  • Aging
  • Malnutrition
  • Physical inactivity
  • Heart and/or kidney failure
  • Type 2 diabetes

Conventional Treatment

  • Encourage food and fluid intake and drug treatment, including DHEA, growth hormone releases, and cannabinoids.
  • It is important to receive proper treatment for the underlying cause of the cachexia.
  • A number of studies have reported that testosterone treatment has been useful in promoting lean weight gain for people with AIDS- or COPD-related cachexia, and can improve protein synthesis and muscle mass in men and women.
Note: Aging individuals who notice their muscle mass begin to decline should have their hormones tested at least once a year. More information is available in the Male and Female Hormone Restoration protocols.

Novel and Emerging Treatments

  • A double-blind study in healthy postmenopausal women reported that a single dose of an experimental drug that inhibits myostatin activity (a protein that limits muscle growth) produced a 5.1% increase in thigh muscle volume compared with a 0.2% reduction with placebo.
  • Beta-adrenergic drugs like formoterol, selective androgen receptors modulators (SARMs) like the investigational drug enobosarm, and the investigational anti-cancer drug selumetinib also increase lean muscle mass.
  • A number of human studies have reported that treatment with ghrelin, a hormone produced in the gut that functions in the central nervous system, is associated with increased appetite, muscle and fat mass, and functional status in people with sarcopenia, cancer, COPD, and end stage renal disease.

Dietary and Lifestyle Considerations

  • Exercise, especially resistance training (eg, lifting weights), is critical for maintaining muscle mass in those with cachexia and sarcopenia, and is most effective when coupled with proper nutrition.
  • Consume adequate protein and amino acids.
  • Avoid smoking.

Integrative Interventions

  • Whey protein: Whey provides has an excellent amino acid profile; it is a rich source of many amino acids vital for muscle building, including the branched chain amino acids leucine, isoleucine, and valine.
  • Creatine: Daily supplementation with creatine has been shown to increase muscle strength and endurance in the elderly while performing daily activities.
  • Amino acids: Leucine’s derivative HMB, along with the amino acids glutamine and arginine, play key roles in treating muscle wasting.
  • L-carnitine: Several published studies have reported that many patients with cancer-related cachexia are often low in carnitine, and daily supplementation is associated with reduced fatigue and increased lean body mass.
  • Omega-3 fatty acids: A British study of older adults reported that consuming higher levels of fatty fish was associated with greater handgrip strength, which is a marker of muscle function.
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